18.417 Introduction to Computational Molecular Biology
Intro to Molecular Biology
Computational Molecular Biology
Why Computational?
Intro to Molecular Biology
DNA: The double helix
DNA: the molecule of heredity
DNA: chemical details
DNA: deoxyribose sugar
DNA: the four bases
DNA: base pairs
DNA: sequences
DNA packaging
Chromosomes inside the cell
Intro to Molecular Biology
Genes control the making of cell parts
RNA: The messenger
From DNA to RNA: Transcription
From pre-mRNA to mRNA: Splicing
RNA can be functional
RNA structure: 2ndary and 3rdary
Splicing machinery
Intro to Molecular Biology
Proteins carry out the cell’s chemistry
Protein structure
Protein building blocks
From RNA to protein: Translation
The Genetic Code
The genetic code
Summary: The Central Dogma
Intro to Molecular Biology
RNA can make DNA
Protein can mediate inheritance
Non-mendelian inheritance rules
Evolutionary shortcuts
Combinatorial Bio-diversity
Our Goal